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12-14-2010, 03:35 PM
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#1 | | Rs has made me the woman i am today!
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| Stem Cell Transplant Cures HIV In 'Berlin Patient'
http://www.huffingtonpost.com/2010/1..._n_796521.html  Quote:
On the heels of World AIDS Day comes a stunning medical breakthrough: Doctors believe an HIV-positive man who underwent a stem cell transplant has been cured as a result of the procedure.
Timothy Ray Brown, also known as the "Berlin Patient," received the transplant in 2007 as part of a lengthy treatment course for leukemia. His doctors recently published a report in the journal Blood affirming that the results of extensive testing "strongly suggest that cure of HIV infection has been achieved."
Brown's case paves a path for constructing a permanent cure for HIV through genetically-engineered stem cells.
Last week, Time named another AIDS-related discovery to its list of the Top 10 Medical Breakthroughs of 2010. Recent studies show that healthy individuals who take antiretrovirals, medicine commonly prescribed for treating HIV, can reduce their risk of contracting the disease by up to 73 percent.
While these developments by no means prove a cure for the virus has been found, they can certainly provide hope for the more than 33 million people living with HIV worldwide. Alongside such findings, global efforts to combat the epidemic have accelerated as of late, with new initiatives emerging in the Philippines and South Africa this week.
| Advancing technology... Simply Amazing!
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12-14-2010, 03:41 PM
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#2 | | Need my Daily Fix of RS
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Very interesting!
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12-14-2010, 04:19 PM
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#3 | | My dinner reheated before my turbo spooled
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Oddly enough, first thing that came to my mind was some American intellectual getting pissed because of the bush admin's ban on stem cell research and now the US is behind.
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12-14-2010, 04:34 PM
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#4 | | My dinner reheated before my turbo spooled
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no way...
I'm going to wait and see..
if so.. that is amazing...
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If we are not able to ask skeptical questions, to interrogate those who tell us that something is true; to be skeptical of those in authority, then we're up for grabs..
-Carl Sagan
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12-14-2010, 04:49 PM
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#5 | | OMGWTFBBQ is a common word I say everyday
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umbilical blood storage just became a viable option
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Originally Posted by Fei-Ji  haha i can taste the cum in my mouth | There is a time when you have to sig a post.
It just happened.
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12-14-2010, 04:50 PM
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#6 | | I WANT MY 10 YEARS BACK FROM RS.net!
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i won't hold my breath unless it's replicable
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12-14-2010, 04:52 PM
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#7 | | Banned By Establishment
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RS meet @ bangkok when the HIV cure is replicable?
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12-14-2010, 06:13 PM
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#8 | This title intentionally left blank MOD
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Originally Posted by BNR32_Coupe RS meet @ bangkok when the HIV cure is replicable? | Except all the other nasty STIs and VD you can get, that AREN'T cured. 
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12-14-2010, 06:24 PM
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#9 | | My dinner reheated before my turbo spooled
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^ Yeah you don't want to get a "herpie" on your Lip (word to Jersey Shore)
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12-14-2010, 07:12 PM
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#10 | | My homepage has been set to RS
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I hope its true!
But I don't see how stem cells can cure a viral disease....maybe it just aids to prevent the symptoms..in any event 
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12-14-2010, 07:39 PM
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#11 | | I WANT MY 10 YEARS BACK FROM RS.net!
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^ many of your white blood cells that compose of your immune system started out being a stem cell
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12-14-2010, 07:43 PM
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#12 | | I *Fwap* *Fwap* *Fwap* to RS
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How was his AIDS cured? Is the term "cured" defined by having a sufficient CD4 count rather than the body being free of the HIV virus itself?
Big step forward for science, things like this experiment (eg. using hematopoetic progenitor cells to make more T-cells) have been going on forever glad to see one of them worked out, now on to the rest of 33 million people in the world who live with HIV =)
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12-14-2010, 09:07 PM
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#13 | | WOAH! i think Vtec just kicked in!
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He wasn't at the AIDS stage -- AIDS (Acquired Immune Deficiency Syndrome) is a patient state where the natural defense T-cells are below a certain number in the body, leaving the host weakened to everyday threats like the flu virus, cancer, bacteria etc etc.
HIV is the virus that causes this condition -- imagine that you are a collection of zillions and zillions of self-replicating bubbles called cells. On the surface of the cells are things called receptors, resembling key holes -- millions of different keyholes for different keys. Viruses are like keys, and when they enter the body and happen to "plug" into a keyhole that fits, trigger shitloads of things to happen. The HIV virus for example, plugs into the the body's defense T-cells, and tells it stop replicating itself, and instead make more HIV viruses ("keys") which in turn infect other T-cells etc.
Under normal circumstances, your body has units that move around and look for foreign dangers such as bacteria or viruses. Once found, these units attack the bacteria or viruses, and present fragments of them to T-cells, which then make other units to look for, and attack the specific bacteria or virus. Such T-cells are termed "activated" as they now have a target in the body.
The HIV virus however, preferentially attacks such "activated" T-cells, rendering the natural defense system weaker.
What this study found, is that by introducing cells that give rise to new T-cells (unactivated), by way of stem cells, these T-cells have effectively managed to rid the body of existing HIV viruses.
Actual PDF of journal here: http://bloodjournal.hematologylibrar...0-09-309591v1# | |
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12-14-2010, 09:09 PM
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#14 | | Banned (ABWS)
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Originally Posted by BNR32_Coupe RS meet @ bangkok when the HIV cure is replicable? | Why did BNR32_Coupe walk into the airport sideway? | |
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12-14-2010, 10:36 PM
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#15 | | Fathered more RS members than anybody else. Who's your daddy?
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| Quote:
Originally Posted by achiam He wasn't at the AIDS stage | Bwahahahaha............
I love the avatar!
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12-15-2010, 02:59 PM
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#16 | | My homepage has been set to RS
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Originally Posted by BNR32_Coupe RS meet @ bangkok when the HIV cure is replicable? | haha it's like the dude in hangover said "remember, what happens in vegas stays in vegas.....except herpes."
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12-15-2010, 03:00 PM
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#17 | | My homepage has been set to RS
Join Date: Dec 2008 Location: Vancouver
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| Quote:
Originally Posted by achiam He wasn't at the AIDS stage -- AIDS (Acquired Immune Deficiency Syndrome) is a patient state where the natural defense T-cells are below a certain number in the body, leaving the host weakened to everyday threats like the flu virus, cancer, bacteria etc etc.
HIV is the virus that causes this condition -- imagine that you are a collection of zillions and zillions of self-replicating bubbles called cells. On the surface of the cells are things called receptors, resembling key holes -- millions of different keyholes for different keys. Viruses are like keys, and when they enter the body and happen to "plug" into a keyhole that fits, trigger shitloads of things to happen. The HIV virus for example, plugs into the the body's defense T-cells, and tells it stop replicating itself, and instead make more HIV viruses ("keys") which in turn infect other T-cells etc.
Under normal circumstances, your body has units that move around and look for foreign dangers such as bacteria or viruses. Once found, these units attack the bacteria or viruses, and present fragments of them to T-cells, which then make other units to look for, and attack the specific bacteria or virus. Such T-cells are termed "activated" as they now have a target in the body.
The HIV virus however, preferentially attacks such "activated" T-cells, rendering the natural defense system weaker.
What this study found, is that by introducing cells that give rise to new T-cells (unactivated), by way of stem cells, these T-cells have effectively managed to rid the body of existing HIV viruses.
Actual PDF of journal here: http://bloodjournal.hematologylibrar...0-09-309591v1# | yes but if you have HIV and you cure it, you won't get AIDS. If this is what they found and they manage to replicate it, all it takes is getting regular HIV tested and curing it if positive, to prevent aids...
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12-15-2010, 03:13 PM
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#18 | | WOAH! i think Vtec just kicked in!
Join Date: Feb 2005 Location: Bowen Island
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| Quote:
Originally Posted by drunkrussian yes but if you have HIV and you cure it, you won't get AIDS. If this is what they found and they manage to replicate it, all it takes is getting regular HIV tested and curing it if positive, to prevent aids... | True! But it's actually more complicated than that.
1.) They had to find a "mutant" strain of stem cell that would give rise to T-cells that would be resistant to the HIV virus - this mutation happens in 1% of all caucasians, and 0% of asians/blacks.
2.) They had to use chemotherapy to kill ALL of the patient's original T-cells, meaning that their natural immune system was killed off to zero, or it would attack the new mutant "foreign" stem cell T-cell. Such procedures have 25-30% fatality rates.
3.) The stem cell replacement therapy is extremely expensive and time consuming, and thus would never be feasible for large populations....
Just the first 2 reasons alone make the statistical success rate (0.01 x 0.25) = 0.0025
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12-15-2010, 03:18 PM
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#19 | | I have named my kids VIC and VLS
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an actual cure for "AIDS" seems unlikely, or in the least, inneffective treating the vast majority of the people with it
prevention like this is really the only way there will be until there is somthing that stops AIDS completely and rebuilds the immune system in one shot
50 million Africans arent going to be lining up for 3 time a week treatments, even when it's free
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