People aged 40 to 74 will be offered blood pressure, weight and cholesterol checks along with lifestyle advice every five years.
The Government says the scheme will save 650 lives a year.
Health authorities will launch the programme on 1 April by writing letters to at-risk groups and inviting them for checks.
More than 2 million people will be assessed each year and and then called back for check-ups every five years.
GPs already carry out checks on about 80 per cent of the age group.
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