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Old 05-26-2009, 10:12 PM   #1
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Mouse genome laid bare to science

Scientists have finished sequencing the mouse genome after a 10-year effort.

The humble mouse is the experimental workhorse in laboratories worldwide, so this high-quality genome sequence will aid in the fight against human disease.

The search for novel treatments could benefit from a greater understanding of the mouse genetic code, which is about 75% similar to our own.

An international team of researchers have published details of the work in the open-access journal PLoS Biology.

The sequence comprises the full complement of genetic material in the nucleus of a cell. It is effectively the genetic "instruction booklet" for a living animal.

The mouse (Mus musculus) becomes only the second mammal after humans to have its complete genome laid bare.

But draft sequences have been published for the chimp, dog, rat, cat, macaque and even the duck-billed platypus.

The mouse is the animal most often used to better understand human illnesses and how they develop.

Research carried out using mice has led to advances in the treatment of cancer, diabetes, heart disease and countless other conditions.

Good model

Co-author Professor Chris Ponting, from the University of Oxford, told BBC News the work confirmed that the mouse was an excellent experimental model for human disease.

"Completion of the genome is extremely important in helping us to identify the genes that underpin biology that is the same across all mammals," he said.

But he said it was also important to separate the genes humans shared with mice from those which differed between them.

About 75% of mouse genes have a single equivalent in humans. But some 5,000 genes arose after the ancestors of mice and humans went their separate evolutionary ways.

"In retrospect, our previous picture of the mouse genome was incomplete," said Dr Leo Goodstadt from the University of Oxford.

"Only when all the missing pieces of the genomic puzzle had been filled in did we realise that we had been missing large numbers of genes found only in mice, and not in humans."

The mouse genome sequencing effort began in 1999, and a draft sequence was published in 2002.

The cost, borne by US and UK sequencing centres, is estimated to exceed $100m (62m).

Some groups oppose animal experimentation, campaigning to ban or limit the animals used.

In the UK, growth in the use of genetically modified (GM) animals - mainly mice - is largely responsible for a steady rise in the numbers of animals used in experiments since 1997.

Professor Ponting, from the Medical Research Council's (MRC) Functional Genomics Unit at Oxford, said the complete genome could provide insights into the evolution of mammals.

Humans and mice share a remarkable level of similarity, despite having evolved independently for the last 90 million years.

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Old 05-27-2009, 07:04 AM   #2
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so when a animals genome is cracked or whatever, what does that mean? we can hack them? hahahahaha.

nipples neways...wat is with those fuck'n asians! i mean you would think they've never seen a dentist in their life. are dentists really that rare over there in ricey ricey and? looks like they're star trek ferrengi rejects! fuck'n have broken glass for teeth! goddaymn! and the smell....did a rat crawl in there and shit itself then marinate in its own shit as it decayed?ewwwwwwwwww! i swear...if one of those ferrengi asian girls gave head...when u pull the dick out it looks like it went thru a meat grinder! prolly shaved off a few slices of meat! *shudder*
Greebo i t-boned some guy and killed their baby, it was funny
silvia i have a couple asian guy friends that do very well with the ladies. but guess what, they go to the gym, they dont have long hair, they dont wear orange pants, and they dont play counterstrike. its not the ethnicity that the girls dont like, its the style and personality.
450HP Supra I am about to use your eye sockets as a shoe rack for my nuts. ...something about chinks, j-bodys, I can't quite remember as I was drunk and looking for a girl to punch in the clit. Think of it as a digital urinal, and you are the mint, except, instead of actually smelling mint, you smell like mothballs, rotten kimchee and virginity. I'm about to start drinking heavily now and you better be gone before I get back or I swear to god I will break the internet over my knee and use the pieces to beat you in the deformed skull with, cock muffler.
Iceman-19 If your gf cooks and cleans, good, tell the guy to take a fucking hike. If she doesnt, fuck, that joker can have her. Lifes too short to cook your own meals and do your own laundry, thats what women are for!
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Old 05-27-2009, 10:05 AM   #3
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hack then overclock by remote
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haha i can taste the cum in my mouth
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organge7 has spoken, and we have done the opposite. yay!
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Old 05-28-2009, 01:02 AM   #4 has a homepage?!
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well mainly to test drugs and experiments on them because of the similar genome to humans.
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Old 05-28-2009, 02:47 AM   #5
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We don't have sufficient cloning technology yet. Not until they figure out how to build nanorobots that can physically assemble the individual molecules that make up the DNA. Then we can start growing limbs for people, genetically pure rats for lab experiments, pieces of chicken for KFC..
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Old 05-28-2009, 07:06 AM   #6
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^ i think they already played with the genes of chickens for the pieces of chicken in KFC
peanut butter jelly, peanut butter jelly, peanut butter jelly with a baseball bat!

Originally Posted by Ulic Qel-Droma View Post
this aint mcdonalds, smiles aren't free.
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