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11-06-2012, 11:08 AM
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#1 | | I WANT MY 10 YEARS BACK FROM RS.net!
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| HIV Vaccine: 1st Clinical Trial Promising Results
Quote:
Researchers in Ontario have put a preventative HIV vaccine to the test for the first time, and say the initial results are an “exciting” step toward creating a commercialized HIV vaccine.
The SAV001-H vaccine, lauded as a one-of-a-kind venture in Canada, was tested on HIV-positive volunteers last spring following approval from the U.S. Food and Drug Administration.
After randomized tests conducted on infected men and women between 18 and 50 years of age, researchers say they’ve observed no adverse physical effects in their volunteers.
“These interim results have proven the safety and efficacy of this vaccine in humans,” Dr. Dong Joon Kim, of Sumagen Co., the biotechnology company that is helping researchers at the University of Western Ontario develop the vaccine.
Unlike other injections, SAV001-H is the first preventative HIV vaccine based on a genetically modified killed whole virus, meaning it includes elements of the virus without causing infection.
The intent behind this strategy -- which has been used in vaccines for polio, the flu, hepatitis A and more -- is to inspire increased antibody production.
Antibodies are proteins in the blood used to fight specific antigens, or infections.
Dr. Chil-Yong Kang, of Western’s Schulich School of Medicine & Dentistry, said the advantage of the “killed whole virus” approach is that it teaches the body how to respond to the virus.
“New responses to native structure will be elicited and it can provide a protective immunity,” he told reporters at a news conference held Tuesday in London, Ont.
Kang said the initial results showed a significant increase in antibody production in participants, without causing any unusual responses to the volunteers’ immune system.
The only minor effect, he said, was that some participants experienced muscle and joint pain at the site of the injections -- similar to the soreness one would feel when getting the flu shot.
It’s estimated that 34 million people around the world have Human Immunodeficiency Virus, a progressive illness that targets the immune system. The last stage of the infection is AIDS.
At last count, in 2008, the Public Health Agency of Canada estimated that approximately 65,000 people in Canada were living with HIV -- a 14-per-cent increase in three years.
Currently, there is no proven cure for AIDS or preventative HIV vaccine in existence, but treatment available can greatly improve one’s quality of life.
Buoyed by the results of the first clinical trial, Kang said his research team at Western will be moving on to phase two: testing the vaccine in humans that are not infected with HIV.
Read more: Promising results follow first test of unique HIV vaccine | CTV News | I hope this pans out..that would leave hep C as the only major communicable disease with no immunizations.
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11-06-2012, 11:55 AM
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#2 | | My homepage has been set to RS
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Don't want to be too pessimistic but this is still far away from potential approval and quite early in the drug development process that it can get rejected for numerous reasons. Still hopeful nonetheless.
"The success rates vary among the different stages of clinical trials. For example, there's a 66% chance companies will get through Phase I, but only a 33% chance of success in Phase II, and a 55% chance in Phase III. Having run that gauntlet, once the drug has been submitted for FDA approval, the success rate is actually 80%." http://www.dailyfinance.com/2011/02/...t-gets-harder/ | |
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11-06-2012, 11:59 AM
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#3 | | Banned By Establishment
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This is pretty exciting and its great to see that after years of research and millions in funding is working.
Although, I hope that the importance of safe-sex is still actively promoted and people (especially younger people) don't take this as a reason not to have protective sex.
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11-06-2012, 12:16 PM
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#4 | | Banned By Establishment
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Just have to remember, no sex with monkeys.
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11-06-2012, 12:24 PM
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#5 | | I have named my kids VIC and VLS
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Never wear domes. Can't get anything If I never get tested
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11-06-2012, 12:30 PM
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#6 | | RS has made me the bitter person i am today!
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so what happens when they have more clinical trials and the vaccine fails 
__________________ There's a phallic symbol infront of my car Quote: |
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11-06-2012, 12:36 PM
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#7 | | I WANT MY 10 YEARS BACK FROM RS.net!
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if you are interested in the process of developing vaccines...the whole process can take 10-15 years http://www.historyofvaccines.org/con...and-regulation | |
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11-06-2012, 12:39 PM
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#8 | | I told him no, what y'all do?
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saw the thread title and the first thing i thought of was Will Smith in I Am Legend
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11-06-2012, 01:46 PM
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#9 | | I don't like cheese but I love milk!
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You can wait for the vaccine, or you get just get rich...
rich people don't die from hiv...  | |
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11-06-2012, 01:58 PM
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#10 | | Banned (ABWS)
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Sorry... do not want. Could you imagine if any batch of the vaccines weren't properly processed and traces of live viruses were present? I mean it's not like a flu shot where the worst case scenario, you get mild flu symptoms.
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11-06-2012, 05:49 PM
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#11 | | OMGWTFBBQ is a common word I say everyday
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Originally Posted by twdm  Sorry... do not want. Could you imagine if any batch of the vaccines weren't properly processed and traces of live viruses were present? I mean it's not like a flu shot where the worst case scenario, you get mild flu symptoms. | actually the flu vaccine can cost anything from being paralyze to death. It is actually written on the leaflet that come with the vaccine but no one actually bother to read it. It a very very very slim chance but it could happen. No vaccine is technically completely safe
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11-06-2012, 09:37 PM
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#12 | | Proud to be called a RS Regular!
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11-06-2012, 10:26 PM
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#13 | | Banned (ABWS)
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Originally Posted by threezero actually the flu vaccine can cost anything from being paralyze to death. It is actually written on the leaflet that come with the vaccine but no one actually bother to read it. It a very very very slim chance but it could happen. No vaccine is technically completely safe | Yes, I know. I actually administer vaccines so I know what the fuck I'm talking about. We're talking about production standards, not rare side effects that happen in one in 100,000 people. ROFL at ignorant idiots who don't even know how low the standards are for IV products. Fail first, think later.
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11-06-2012, 11:50 PM
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#14 | | My dinner reheated before my turbo spooled
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Originally Posted by yray so what happens when they have more clinical trials and the vaccine fails | then zombies, bro
__________________ Quote:
If we are not able to ask skeptical questions, to interrogate those who tell us that something is true; to be skeptical of those in authority, then we're up for grabs..
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11-07-2012, 12:00 AM
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#15 | | I WANT MY 10 YEARS BACK FROM RS.net!
Join Date: Oct 2007 Location: Vancouver BC
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Originally Posted by twdm Yes, I know. I actually administer vaccines so I know what the fuck I'm talking about. We're talking about production standards, not rare side effects that happen in one in 100,000 people. ROFL at ignorant idiots who don't even know how low the standards are for IV products. Fail first, think later. | then you would know it's not that different from say BCG or influenza vaccines
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11-07-2012, 06:45 AM
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#16 | | What hasn't Killed me, has made me more tolerant of RS!
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going to be like the movie "i am legend" soon lulzz
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11-07-2012, 05:16 PM
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#17 | | Banned (ABWS)
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Originally Posted by twitchyzero then you would know it's not that different from say BCG or influenza vaccines | The difference is HIV is incurable serious infection whereas tuberculosis is curable, and influenza is self-limiting.
My mind is so full of fuck at your fail logic.
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11-07-2012, 05:52 PM
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#18 | | what manner of phaggotry is this
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calm down noob
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11-07-2012, 07:52 PM
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#19 | | I WANT MY 10 YEARS BACK FROM RS.net!
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Originally Posted by twdm The difference is HIV is incurable serious infection whereas tuberculosis is curable, and influenza is self-limiting.
My mind is so full of fuck at your fail logic. | the flu might be self-limiting in the general pop'n...yet those in the high risk pop'n (old/young/pregnant/medically compromised) that are prioritized to get them can easily become hospitalized.
If you are such a logic nazi please find me some credible literature suggesting attenuated vaccines are counter-productive. Or perhaps the big pharma is covering it up and that I should get my tin foil hat out 
So lemme get this straight...before you jab someone in the arm you tell the individual "these have pretty crappy standards...you'll likely get sick but hey I'm just doing my job!"  | |
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11-07-2012, 09:38 PM
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#20 | | Banned By Establishment
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Well, I wouldn't want to be the first guy to raw dog it hoping some guy did his job right.
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11-08-2012, 02:55 AM
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#21 | | Marcosexual Fan Club, CEO
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Am I missing something? The article doesn't state anything about the efficacy of the drug or even if it works as a vaccine. Based on the article, it appears that the testing only shows that the drug has minimal side effects, not that it actually works.
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11-08-2012, 07:01 AM
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#22 | | Banned (ABWS)
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Originally Posted by twitchyzero So lemme get this straight...before you jab someone in the arm you tell the individual "these have pretty crappy standards...you'll likely get sick but hey I'm just doing my job!" | What part don't you understand. In the unlikely chance that the product was not prepared properly, you get HIV. Do you want to take the risk? Why not just practice safe sex?
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11-08-2012, 06:34 PM
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#23 | | My dinner reheated before my turbo spooled
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^ nothing is 100%.. Only way to completely be safe is abstinence... and that would kind of suck.
__________________ Quote:
If we are not able to ask skeptical questions, to interrogate those who tell us that something is true; to be skeptical of those in authority, then we're up for grabs..
-Carl Sagan
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11-08-2012, 06:50 PM
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#24 | | Everyone wants a piece of R S...
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Cant get AIDS from butt sex right??
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11-08-2012, 06:51 PM
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#25 | | iceboy & saucywoman are my parents!
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great... that good news.
only problem i see is that the virus might adapt to the vaccine making the vaccine useless.. then we will have one big fuck up on our hands
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